Correlation between epidermal growth factor receptor, anaplastic lymphoma kinase and programmed cell death-ligand-1 expression and survival in patients with pulmonary adenocarcinoma

Correlación entre la expresión y supervivencia del receptor del factor de crecimiento epidermal, la quinasa del linfoma anaplásico y el ligando-1 de la muerte celular programada en pacientes con adenocarcinoma pulmonar

Resumen

Lung cancer is the leading cause of cancer incidence and mortality worldwide, accounting for 12.4 % of all reported cases. This study aims to investigate the relationship between patient survival and the expression of the markers EGFR, ALK, and PD-L1 in patients with lung adenocarcinoma. Methods: A prospective cohort study was conducted at a cancer treatment center in Barranquilla, Colombia, involving patients aged 18 and older diagnosed with adenocarcinoma. Patient data, including demographics, tumor markers (EGFR, ALK, PD-L1), smoking history, and clinical outcomes, were collected. Statistical analyses included the Kolmogorov-Smirnov test, Kruskal-Wallis’ test, Fisher’s exact test, and Kaplan-Meier survival analysis. Results: The study included 193 patients, predominantly female (53 %), with a median age of 68 years. Most patients were from urban areas (86 %) and were smokers (48 %). The study found a high prevalence of poorly differentiated adenocarcinoma (54 %) and stage IV disease (86 %).