Analysis of the Relationship Between Soluble Cd40 Ligand and Homeostasis Model Assessment of Insulin Resistance in Obese Non-Diabetic Subjects

Autores/as

  • Nur Ismi Deparment of Biomedical Science, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Uleng Bahrun Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
  • Liong Boy Kurniawan Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
  • Andi Alfian Zainuddin Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Siti Rafiah Department of Anatomi, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Himawan Sanusi Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Palabras clave:

Obesity, HOMA-IR, sCD40L

Resumen

Obesity is a complex multifactorial disease characterized by the accumulation of body fat, leading to adverse effects on one’s well-being. Obesity has a strong association with insulin resistance. Insulin resistance can lead to a range of health issues, including type II diabetes mellitus, cardiovascular disease, and other metabolic syndrome diseases. A method that can be employed to evaluate insulin resistance is the measurement of HOMA-IR. sCD40L is the soluble form of the CD40L molecule released on the cell surface through proteolysis. There is evidence that the sCD40L level is a strong predictor of cardiovascular risk, and enhanced levels of CD40L were reported in patients with hypercholesterolemia, diabetes mellitus, and acute coronary syndromes.

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Biografía del autor/a

Nur Ismi, Deparment of Biomedical Science, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Uleng Bahrun, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.



Andi Alfian Zainuddin, Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Siti Rafiah, Department of Anatomi, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Himawan Sanusi, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia



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Publicado

13-12-2024

Cómo citar

Ismi, N. ., Bahrun, U. ., Kurniawan, L. B. ., Zainuddin, A. A. ., Rafiah, S. ., & Sanusi, H. . (2024). Analysis of the Relationship Between Soluble Cd40 Ligand and Homeostasis Model Assessment of Insulin Resistance in Obese Non-Diabetic Subjects. Gaceta Médica De Caracas, 132(4). Recuperado a partir de http://repositoriolinux.ucv.ve/ojs/index.php/rev_gmc/article/view/29955

Número

Vol. 132 Núm. 4 (2024)

Sección

ARTÍCULOS ORIGINALES

Licencia

Derechos de autor 2024 Gaceta Médica de Caracas

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

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